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Publikationen

2015

Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease.
Kuehn F, Klar E, Bliemeister A, Linnebacher M.
World J Gastroenterol. 2015 Jan 7;21(1):221-8. doi: 10.3748/wjg.v21.i1.221.

Establishment and characterization of cell lines from chromosomal instable colorectal cancer.
Maletzki C, Gock M, Randow M, Klar E, Huehns M, Prall F, Linnebacher M.
World J Gastroenterol. 2015 Jan 7;21(1):164-76. doi: 10.3748/wjg.v21.i1.164.

Determinant-based classification of severity of acute pancreatitis: have we really reached consensus?
Talukdar R, Rau BM.
Ann Surg. 2015 Jan;261(1):e22. doi: 10.1097/SLA.0000000000000507

Arginine deprivation by Arginine Deiminase of Streptococcus pyogenes controls primary glioblastoma growth in vitro and in vivo.
Fiedler T, Strauss M, Hering S, Redanz U, William D, Rosche Y, Classen CF, Kreikemeye B, Linnebacher M, Maletzk C.
Cancer Biol Ther. 2015 Mar 16:0.

MicroRNA-mRNA interactions in colorectal cancer and their role in tumor progression.
Amirkhah R, Schmitz U, Linnebacher M, Wolkenhauer O, Farazmand A.
Genes Chromosomes Cancer. 2015 Mar;54(3):129-41. doi: 10.1002/gcc.22231.


2014

Endoscopic continuity-preserving therapy for esophageal stenosis and perforation following colliquative necrosis.
Kuehn F, Klar E, Schwandner F, Alsfasser G, Gock M, Schiffmann L.
Endoscopy. 2014;46 Suppl 1 UCTN:E361-2. doi: 10.1055/s-0034-1377283. Epub 2014 Sep 25

Influence of local hemostatic and antiplatelet agents on the incidence of bleeding complications in carotid endarterectomies.
Weinrich M, Schindler P, Kundt G, Klar E, Bünger CM.
Clin Hemorheol Microcirc. 2014;58(1):271-9. doi: 10.3233/CH-141901.

VEGF-releasing suture material for enhancement of vascularization: development, in vitro and in vivo study.
Bigalke C, Luderer F, Wulf K, Storm T, Löbler M, Arbeiter D, Rau BM, Nizze H, Vollmar B, Schmitz KP, Klar E, Sternberg K.
Acta Biomater. 2014 Dec;10(12):5081-9. doi: 10.1016/j.actbio.2014.09.002. Epub 2014 Sep 7

Gastric gastrointestinal stromal tumor lost in the peritoneum after endoscopic resection.
Schwandner F, Klar E, Schiffmann L.
Endoscopy. 2014;46 Suppl 1 UCTN:E349. doi: 10.1055/s-0034-1365814. Epub 2014 Aug 14.

Treatment of a subsequently detected, iatrogenic colonic perforation via minimal-invasive rendezvous procedure.
Kühn F, Philipp M, Klar E, Witte M.
Z Gastroenterol. 2014 Aug;52(8):818-20. doi: 10.1055/s-0034-1366615. Epub 2014 Aug 11. German

[Venous Access Port Implantation is an Ideal Teaching Operation - An Analysis of 1423 Cases.]
Alsfasser G, Neumann A, Klar E, Eisold S.
Zentralbl Chir. 2014 Jul 30. [Epub ahead of print] German.

[Loss of domain-a surgeon's challenge. Surgical approach to an enormous scrotal hernia].
Philipp M, Förster S, Klar E.
Chirurg. 2014 Nov;85(11):1005-9. doi: 10.1007/s00104-014-2789-8. German.

Host defense peptides for treatment of colorectal carcinoma - a comparative in vitro and in vivo analysis.
Maletzki C, Klier U, Marinkovic S, Klar E, Andrä J, Linnebacher M.
Oncotarget. 2014 Jun 30;5(12):4467-79.

Future perspectives for surgical research in Germany.
Diener MK, Menger MD, Jähne J, Saeger HD, Klar E.
Langenbecks Arch Surg. 2014 Mar;399(3):253-62. doi: 10.1007/s00423-014-1178-6. Epub 2014 Mar 11. Erratum in: Langenbecks Arch Surg. 2014 Jun;399(5):677.

[Endoscopic vacuum therapy after iatrogenic oesophageal perforation--a case report].
Kühn F, Rau BM, Klar E, Schiffmann L.
Zentralbl Chir. 2014 Feb;139(1):98-100. doi: 10.1055/s-0032-1328100. Epub 2013 Apr 25. German.

Liver resections of isolated liver metastasis in breast cancer: results and possible prognostic factors.
Weinrich M, Weiß C, Schuld J, Rau BM.
HPB Surg. 2014;2014:893829. doi: 10.1155/2014/893829. Epub 2014 Jan 19.

Preparing for prospective clinical trials: a national initiative of an excellence registry for consecutive pancreatic cancer resections.
Rau BM.
World J Surg. 2014 Feb;38(2):463-4. doi: 10.1007/s00268-013-2357-2.

E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.
Wiegering A, Korb D, Thalheimer A, Kämmerer U, Allmanritter J, Matthes N, Linnebacher M, Schlegel N, Klein I, Ergün S, Germer CT, Otto C.
Neoplasia. 2014 Nov 20;16(11):972-81. doi: 10.1016/j.neo.2014.09.008. eCollection 2014 Nov

Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
Lange F, Franz B, Maletzki C, Linnebacher M, Hühns M, Jaster R.
Biomed Res Int. 2014;2014:568693. doi: 10.1155/2014/568693. Epub 2014 Sep 17.

Accounting for randomness in measurement and sampling in studying cancer cell population dynamics.
Ghavami S, Wolkenhauer O, Lahouti F, Ullah M, Linnebacher M.
IET Syst Biol. 2014 Oct;8(5):230-41. doi: 10.1049/iet-syb.2013.0031.

Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.
Haustein M, Ramer R, Linnebacher M, Manda K, Hinz B.
Biochem Pharmacol. 2014 Nov 15;92(2):312-25. doi: 10.1016/j.bcp.2014.07.014. Epub 2014 Jul 25.

The impact of pyrvinium pamoate on colon cancer cell viability.
Wiegering A, Uthe FW, Hüttenrauch M, Mühling B, Linnebacher M, Krummenast F, Germer CT, Thalheimer A, Otto C.
Int J Colorectal Dis. 2014 Oct;29(10):1189-98. doi: 10.1007/s00384-014-1975-y. Epub 2014 Jul 26.

PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: two hits on the gene?
Hühns M, Salem T, Schneider B, Krohn M, Linnebacher M, Prall F.
Oncol Rep. 2014 May;31(5):2236-44. doi: 10.3892/or.2014.3097. Epub 2014 Mar 19.


2013

[S3-guideline exocrine pancreatic cancer].
Seufferlein T, Porzner M, Becker T, Budach V, Ceyhan G, Esposito I, Fietkau R, Follmann M, Friess H, Galle P, Geißler M, Glanemann M, Gress T, Heinemann V, Hohenberger W, Hopt U, Izbicki J, Klar E, Kleeff J, Kopp I, Kullmann F, Langer T, Langrehr J, Lerch M, Löhr M, Lüttges J, Lutz M, Mayerle J, Michl P, Möller P, Molls M, Münter M, Nothacker M, Oettle H, Post S, Reinacher-Schick A, Röcken C, Roeb E, Saeger H, Schmid R, Schmiegel W, Schoenberg M, Siveke J, Stuschke M, Tannapfel A, Uhl W, Unverzagt S, van Oorschot B, Vashist Y, Werner J, Yekebas E; Guidelines Programme Oncology AWMF; German Cancer Society eV; German Cancer Aid.
Z Gastroenterol. 2013 Dec;51(12):1395-440. doi: 10.1055/s-0033-1356220. Epub 2013 Dec 11. German

Intensified neoadjuvant radiochemotherapy for rectal cancer enhances surgical complications.
Schiffmann L, Wedermann N, Gock M, Prall F, Klautke G, Fietkau R, Rau B, Klar E.
BMC Surg. 2013 Sep 30;13:43. doi: 10.1186/1471-2482-13-43.

IAP/APA evidence-based guidelines for the management of acute pancreatitis.
Working Group IAP/APA Acute Pancreatitis Guidelines.
Pancreatology. 2013 Jul-Aug;13(4 Suppl 2):e1-15. doi: 10.1016/j.pan.2013.07.063.

Acute cholecystitis: early versus delayed cholecystectomy, a multicenter randomized trial (ACDC study, NCT00447304).
Gutt CN, Encke J, Köninger J, Harnoss JC, Weigand K, Kipfmüller K, Schunter O, Götze T, Golling MT, Menges M, Klar E, Feilhauer K, Zoller WG, Ridwelski K, Ackmann S, Baron A, Schön MR, Seitz HK, Daniel D, Stremmel W, Büchler MW.
Ann Surg. 2013 Sep;258(3):385-93. doi: 10.1097/SLA.0b013e3182a1599b.

Prognosis of rectal cancer patients improves with downstaging by intensified neoadjuvant radiochemotherapy - a matched pair analysis.
Schiffmann L, Klautke G, Wedermann N, Gock M, Prall F, Fietkau R, Rau B, Klar E.
BMC Cancer. 2013 Aug 16;13:388. doi: 10.1186/1471-2407-13-388.

Scoring of human acute pancreatitis: state of the art.
Alsfasser G, Rau BM, Klar E.
Langenbecks Arch Surg. 2013 Aug;398(6):789-97. doi: 10.1007/s00423-013-1087-0. Epub 2013 May 17. Review

[Endoscopic vacuum therapy after iatrogenic oesophageal perforation--a case report].
Kühn F, Rau BM, Klar E, Schiffmann L.
Zentralbl Chir. 2014 Feb;139(1):98-100. doi: 10.1055/s-0032-1328100. Epub 2013 Apr 25. German

Is the lymph node ratio superior to the Union for International Cancer Control (UICC) TNM system in prognosis of colon cancer?
Schiffmann L, Eiken AK, Gock M, Klar E.
World J Surg Oncol. 2013 Mar 23;11:79. doi: 10.1186/1477-7819-11-79.

Reperfusion of liver graft during transplantation: techniques used in transplant centres within Eurotransplant and meta-analysis of the literature.
Manzini G, Kremer M, Houben P, Gondan M, Bechstein WO, Becker T, Berlakovich GA, Friess H, Guba M, Hohenberger W, Ijzermans JN, Jonas S, Kalff JC, Klar E, Klempnauer J, Lerut J, Lippert H, Lorf T, Nadalin S, Nashan B, Otto G, Paul A, Pirenne J, Pratschke J, Ringers J, Rogiers X, Schilling MK, Seehofer D, Senninger N, Settmacher U, Stippel DL, Tscheliessnigg K, Ysebaert D, Binder H, Schemmer P.
Transpl Int. 2013 May;26(5):508-16. doi: 10.1111/tri.12083. Epub 2013 Mar 21. Review.

The "North German Tumor Bank of Colorectal Cancer": status report after the first 2 years of support by the German Cancer Aid Foundation.
Oberländer M, Linnebacher M, König A, Bogoevska V, Brodersen C, Kaatz R, Krohn M, Hackmann M, Ingenerf J, Christoph J, Mate S, Prokosch HU, Yekebas EF, Thorns C, Büning J, Prall F, Uhlig R, Roblick UJ, Izbicki JR, Klar E, Bruch HP, Vollmar B, Habermann JK; ColoNet consortium.
Langenbecks Arch Surg. 2013 Feb;398(2):251-8. doi: 10.1007/s00423-012-1043-4. Epub 2013 Jan 8.

Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus.
Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS; Acute Pancreatitis Classification Working Group.
Gut. 2013 Jan;62(1):102-11. doi: 10.1136/gutjnl-2012-302779. Epub 2012 Oct 25.

[Determinant-based classification of acute pancreatitis severity. International multidisciplinary classification of acute pancreatitis severity: the 2013 German edition].
Layer P, Dellinger EP, Forsmark CE, Lévy P, Maraví-Poma E, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Petrov MS; Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA).
Z Gastroenterol. 2013 Jun;51(6):544-50. doi: 10.1055/s-0033-1335526. Epub 2013 Jun 5. Review. German.

Combinations of TLR ligands: a promising approach in cancer immunotherapy.
Stier S, Maletzki C, Klier U, Linnebacher M.
Clin Dev Immunol. 2013;2013:271246. doi: 10.1155/2013/271246. Epub 2013 Nov 25.

Microsatellite instability in hematological malignancies: Hypermutation vs. immune control-who is challenging who?
Maletzki C, Stier S, Linnebacher M.
Oncoimmunology. 2013 Aug 1;2(8):e25419. Epub 2013 Jul 1.

Establishment and characterization of primary glioblastoma cell lines from fresh and frozen material: a detailed comparison.
Mullins CS, Schneider B, Stockhammer F, Krohn M, Classen CF, Linnebacher M.
PLoS One. 2013 Aug 7;8(8):e71070. doi: 10.1371/journal.pone.0071070. eCollection 2013.

Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib.
Ramer R, Walther U, Borchert P, Laufer S, Linnebacher M, Hinz B.
J Lipid Res. 2013 Nov;54(11):3116-29. doi: 10.1194/jlr.M042283. Epub 2013 Aug 12.

Mistletoe lectin has a shiga toxin-like structure and should be combined with other Toll-like receptor ligands in cancer therapy.
Maletzki C, Linnebacher M, Savai R, Hobohm U.
Cancer Immunol Immunother. 2013 Aug;62(8):1283-92. doi: 10.1007/s00262-013-1455-1. Epub 2013 Jul 6.

Cilengitide response in ultra-low passage glioblastoma cell lines: relation to molecular markers.
Mullins CS, Schubert J, Schneider B, Linnebacher M, Classen CF.
J Cancer Res Clin Oncol. 2013 Aug;139(8):1425-31. doi: 10.1007/s00432-013-1457-6. Epub 2013 Jun 8.

Frameshift-derived neoantigens constitute immunotherapeutic targets for patients with microsatellite-instable haematological malignancies: frameshift peptides for treating MSI+ blood cancers.
Maletzki C, Schmidt F, Dirks WG, Schmitt M, Linnebacher M.
Eur J Cancer. 2013 Jul;49(11):2587-95. doi: 10.1016/j.ejca.2013.02.035. Epub 2013 Apr 2.

Tumor-infiltrating B cells come into vogue.
Linnebacher M.
World J Gastroenterol. 2013 Jan 7;19(1):8-11. doi: 10.3748/wjg.v19.i1.8.

Single nucleotide polymorphism array analysis of microsatellite-stable, diploid/near-diploid colorectal carcinomas without the CpG island methylator phenotype.
Linnebacher M, Ostwald C, Koczan D, Salem T, Schneider B, Krohn M, Ernst M, Prall F.
Oncol Lett. 2013 Jan;5(1):173-178. Epub 2012 Oct 30.

COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.
Ramer R, Heinemann K, Merkord J, Rohde H, Salamon A, Linnebacher M, Hinz B.
Mol Cancer Ther. 2013 Jan;12(1):69-82. doi: 10.1158/1535-7163.MCT-12-0335. Epub 2012 Dec 7.


2012

Multidrug strategies are effective in the treatment of severe experimental pancreatitis.
Werner J, Hartwig W, Hackert T, Kaiser H, Schmidt J, Gebhard MM, Büchler MW, Klar E.
Surgery. 2012 Mar;151(3):372-81. doi: 10.1016/j.surg.2011.07.041. Epub 2011 Oct 6.

Immunosuppressants accelerate microvascular thrombus formation in vivo: role of endothelial cell activation.
Püschel A, Lindenblatt N, Katzfuss J, Vollmar B, Klar E.
Surgery. 2012 Jan;151(1):26-36. doi: 10.1016/j.surg.2011.06.026. Epub 2011 Oct 22

Bacterial immunotherapy of gastrointestinal tumors.
Linnebacher M, Maletzki C, Klier U, Klar E.
Langenbecks Arch Surg. 2012 Apr;397(4):557-68. doi: 10.1007/s00423-011-0892-6. Epub 2011 Dec 22. Review

[Surgical expertise in the management of abdominal injuries from the perspective of general and GI surgery. Reality of care at a level-1 trauma centre].
Klar E; German Society of Trauma Surgery.
Unfallchirurg. 2012 Jan;115(1):35-7. doi: 10.1007/s00113-011-2107-6. German.

Combining bacterial-immunotherapy with therapeutic antibodies: a novel therapeutic concept.
Klier U, Maletzki C, Kreikemeyer B, Klar E, Linnebacher M.
Vaccine. 2012 Apr 5;30(17):2786-94. doi: 10.1016/j.vaccine.2012.01.071. Epub 2012 Feb 13.

Treatment of necrotizing pancreatitis: redefining the role of surgery.
Alsfasser G, Schwandner F, Pertschy A, Hauenstein K, Foitzik T, Klar E.
World J Surg. 2012 May;36(5):1142-7. doi: 10.1007/s00268-012-1504-5.

Ex-vivo clonally expanded B lymphocytes infiltrating colorectal carcinoma are of mature immunophenotype and produce functional IgG.
Maletzki C, Jahnke A, Ostwald C, Klar E, Prall F, Linnebacher M.
PLoS One. 2012;7(2):e32639. doi: 10.1371/journal.pone.0032639. Epub 2012 Feb 29.

Acute mesenteric ischemia: a vascular emergency.
Klar E, Rahmanian PB, Bücker A, Hauenstein K, Jauch KW, Luther B.
Dtsch Arztebl Int. 2012 Apr;109(14):249-56. doi: 10.3238/arztebl.2012.0249. Epub 2012 Apr 6. Review.

A novel sialyl Le(X) expression score as a potential prognostic tool in colorectal cancer.
Schiffmann L, Schwarz F, Linnebacher M, Prall F, Pahnke J, Krentz H, Vollmar B, Klar E.
World J Surg Oncol. 2012 May 23;10:95. doi: 10.1186/1477-7819-10-95.

Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial.
Rödel C, Liersch T, Becker H, Fietkau R, Hohenberger W, Hothorn T, Graeven U, Arnold D, Lang-Welzenbach M, Raab HR, Sülberg H, Wittekind C, Potapov S, Staib L, Hess C, Weigang-Köhler K, Grabenbauer GG, Hoffmanns H, Lindemann F, Schlenska-Lange A, Folprecht G, Sauer R; German Rectal Cancer Study Group.
Lancet Oncol. 2012 Jul;13(7):679-87. doi: 10.1016/S1470-2045(12)70187-0. Epub 2012 May 23.

Volume-outcome relationship in pancreatic surgery: the situation in Germany.
Alsfasser G, Kittner J, Eisold S, Klar E.
Surgery. 2012 Sep;152(3 Suppl 1):S50-5. doi: 10.1016/j.surg.2012.05.011. Epub 2012 Jul 3.

R1 resection in pancreatic cancer has significant impact on long-term outcome in standardized pathology modified for routine use.
Rau BM, Moritz K, Schuschan S, Alsfasser G, Prall F, Klar E.
Surgery. 2012 Sep;152(3 Suppl 1):S103-11. doi: 10.1016/j.surg.2012.05.015. Epub 2012 Jul 3

Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature.
Kühn F, Dieterich M, Klar E, Gerber B, Prinz C.
Geburtshilfe Frauenheilkd. 2012 Aug;72(8):740-743.

Surgical endoscopic vacuum therapy for anastomotic leakage and perforation of the upper gastrointestinal tract.
Kuehn F, Schiffmann L, Rau BM, Klar E.
J Gastrointest Surg. 2012 Nov;16(11):2145-50. doi: 10.1007/s11605-012-2014-3. Epub 2012 Sep 5

Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus.
Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS; Acute Pancreatitis Classification Working Group.
Gut. 2013 Jan;62(1):102-11. doi: 10.1136/gutjnl-2012-302779. Epub 2012 Oct 25.

[S3-Consensus guidelines on definition, etiology, diagnosis and medical, endoscopic and surgical management of chronic pancreatitis German Society of Digestive and Metabolic Diseases (DGVS)].
Chronic Pancreatitis German Society of Digestive and Metabolic Diseases (DGVS), Hoffmeister A, Mayerle J, Beglinger C, Büchler MW, Bufler P, Dathe K, Fölsch UR, Friess H, Izbicki J, Kahl S, Klar E, Keller J, Knoefel WT, Layer P, Loehr M, Meier R, Riemann JF, Rünzi M, Schmid RM, Schreyer A, Tribl B, Werner J, Witt H, Mössner J, Lerch MM.
Z Gastroenterol. 2012 Nov;50(11):1176-224. doi: 10.1055/s-0032-1325479. Epub 2012 Nov 13. German.

[Method report to the S3 guideline chronic pancreatitis: definition, etiology, diagnostics and conservative, interventional endoscopic and surgical therapy of the chronic pancreatitis].
Hoffmeister A, Mayerle J, Dathe K, Mössner J, Lerch MM; Mitglieder der Leitlinienkommission.
Z Gastroenterol. 2012 Nov;50(11):1225-36. doi: 10.1055/s-0032-1325447. Epub 2012 Nov 13. German

IAP/APA evidence-based guidelines for the management of acute pancreatitis.
Working Group IAP/APA Acute Pancreatitis Guidelines.
Pancreatology. 2013 Jul-Aug;13(4 Suppl 2):e1-15. doi: 10.1016/j.pan.2013.07.063.

Interventions for necrotizing pancreatitis: summary of a multidisciplinary consensus conference.
Freeman ML, Werner J, van Santvoort HC, Baron TH, Besselink MG, Windsor JA, Horvath KD, vanSonnenberg E, Bollen TL, Vege SS; International Multidisciplinary Panel of Speakers and Moderators.
Pancreas. 2012 Nov;41(8):1176-94. doi: 10.1097/MPA.0b013e318269c660.

Establishment, characterization and chemosensitivity of three mismatch repair deficient cell lines from sporadic and inherited colorectal carcinomas.
Maletzki C, Stier S, Gruenert U, Gock M, Ostwald C, Prall F, Linnebacher M.
PLoS One. 2012;7(12):e52485. doi: 10.1371/journal.pone.0052485. Epub 2012 Dec 31

Single nucleotide polymorphism array analysis of microsatellite-stable, diploid/near-diploid colorectal carcinomas without the CpG island methylator phenotype.
Linnebacher M, Ostwald C, Koczan D, Salem T, Schneider B, Krohn M, Ernst M, Prall F.
Oncol Lett. 2013 Jan;5(1):173-178. Epub 2012 Oct 30.

COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.
Ramer R, Heinemann K, Merkord J, Rohde H, Salamon A, Linnebacher M, Hinz B.
Mol Cancer Ther. 2013 Jan;12(1):69-82. doi: 10.1158/1535-7163.MCT-12-0335. Epub 2012 Dec 7.

Reevaluating the concept of treating experimental tumors with a mixed bacterial vaccine: Coley's Toxin.
Maletzki C, Klier U, Obst W, Kreikemeyer B, Linnebacher M.
Clin Dev Immunol. 2012;2012:230625. doi: 10.1155/2012/230625. Epub 2012 Nov 11.

Tumor-infiltrating B cells: The ignored players in tumor immunology.
Linnebacher M, Maletzki C.
Oncoimmunology. 2012 Oct 1;1(7):1186-1188.

Human endogenous retroviruses and cancer: causality and therapeutic possibilities.
Mullins CS, Linnebacher M.
World J Gastroenterol. 2012 Nov 14;18(42):6027-35. doi: 10.3748/wjg.v18.i42.6027. Review

Microdensitometry of osteopontin as an immunohistochemical prognostic biomarker in colorectal carcinoma tissue microarrays: potential and limitations of the method in 'biomarker pathology'.
Prall F, Maletzki C, Linnebacher M.
Histopathology. 2012 Nov;61(5):823-32. doi: 10.1111/j.1365-2559.2012.04285.x. Epub 2012 Oct 16.

Clonality characterization of natural epitope-specific antibodies against the tumor-related antigen topoisomerase IIa by peptide chip and proteome analysis: a pilot study with colorectal carcinoma patient samples.
Linnebacher M, Lorenz P, Koy C, Jahnke A, Born N, Steinbeck F, Wollbold J, Latzkow T, Thiesen HJ, Glocker MO.
Anal Bioanal Chem. 2012 Apr;403(1):227-38. doi: 10.1007/s00216-012-5781-5. Epub 2012 Feb 16.

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.
Ramer R, Bublitz K, Freimuth N, Merkord J, Rohde H, Haustein M, Borchert P, Schmuhl E, Linnebacher M, Hinz B.
FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23

Endogenous retrovirus sequences as a novel class of tumor-specific antigens: an example of HERV-H env encoding strong CTL epitopes.
Mullins CS, Linnebacher M.
Cancer Immunol Immunother. 2012 Jul;61(7):1093-100. doi: 10.1007/s00262-011-1183-3. Epub 2011 Dec 21.

Therapeutical doses of temozolomide do not impair the function of dendritic cells and CD8+ T cells.
Xu X, Stockhammer F, Schmitt A, Casalegno-Garduno R, Enders A, Mani J, Classen CF, Linnebacher M, Freund M, Schmitt M.
Int J Oncol. 2012 Mar;40(3):764-72. doi: 10.3892/ijo.2011.1269. Epub 2011 Nov 23


2011

Influence of local hemostatic and antiplatelet agents on the incidence of bleeding complications in carotid endarterectomies.
Weinrich M, Schindler P, Kundt G, Klar E, Bünger CM.
Clin Hemorheol Microcirc. 2014;58(1):271-9. doi: 10.3233/CH-141901.

Surgical endoscopic vacuum therapy for anastomotic leakage and perforation of the upper gastrointestinal tract.
Kuehn F, Schiffmann L, Rau BM, Klar E.
J Gastrointest Surg. 2012 Nov;16(11):2145-50. doi: 10.1007/s11605-012-2014-3. Epub 2012 Sep 5.

Bacterial immunotherapy of gastrointestinal tumors.
Linnebacher M, Maletzki C, Klier U, Klar E.
Langenbecks Arch Surg. 2012 Apr;397(4):557-68. doi: 10.1007/s00423-011-0892-6. Epub 2011 Dec 22. Review

Immunosuppressants accelerate microvascular thrombus formation in vivo: role of endothelial cell activation.
Püschel A, Lindenblatt N, Katzfuss J, Vollmar B, Klar E.
Surgery. 2012 Jan;151(1):26-36. doi: 10.1016/j.surg.2011.06.026. Epub 2011 Oct 22.

Multidrug strategies are effective in the treatment of severe experimental pancreatitis.
Werner J, Hartwig W, Hackert T, Kaiser H, Schmidt J, Gebhard MM, Büchler MW, Klar E.
Surgery. 2012 Mar;151(3):372-81. doi: 10.1016/j.surg.2011.07.041. Epub 2011 Oct 6.

[Commentary to: Laparoscopic pancreas head resection. Viability and perioperative results].
Klar E, Hermeneit S.
Chirurg. 2011 Aug;82(8):698-9; discussion 699-700. doi: 10.1007/s00104-011-2088-6. German.

[Pancreas-preserving duodenectomy in acute situations. Surgical treatment of an iatrogenic hemorrhage in the duodenal wall].
Moritz K, Weinrich M, Kröger JC, Klar E.
Chirurg. 2011 Aug;82(8):723-6. doi: 10.1007/s00104-011-2144-2. German.

Multidrug-resistance proteins are weak tumor associated antigens for colorectal carcinoma.
Mullins CS, Eisold S, Klar E, Linnebacher M.
BMC Immunol. 2011 Jul 10;12:38. doi: 10.1186/1471-2172-12-38

DTG procurement guidelines in heart beating donors.
Wunderlich H, Brockmann JG, Voigt R, Rauchfuss F, Pascher A, Brose S, Binner C, Bittner H, Klar E; Commission of Organ Donation and Removal German Transplantation Society.
Transpl Int. 2011 Jul;24(7):733-57. doi: 10.1111/j.1432-2277.2011.01266.x

Impact of portal branch ligation on tissue regeneration, microcirculatory response and microarchitecture in portal blood-deprived and undeprived liver tissue.
Gock M, Eipel C, Linnebacher M, Klar E, Vollmar B.
Microvasc Res. 2011 May;81(3):274-80. doi: 10.1016/j.mvr.2011.03.005. Epub 2011 Mar 21

Extracorporeal cell therapy of septic shock patients with donor granulocytes: a pilot study.
Altrichter J, Sauer M, Kaftan K, Birken T, Gloger D, Gloger M, Henschel J, Hickstein H, Klar E, Koball S, Pertschy A, Nöldge-Schomburg G, Vagts DA, Mitzner SR.
Crit Care. 2011;15(2):R82. doi: 10.1186/cc10076. Epub 2011 Mar 3

Pharmacokinetics and penetration of moxifloxacin into infected diabetic foot tissue in a large diabetic patient cohort.
Majcher-Peszynska J, Sass M, Schipper S, Czaika V, Gussmann A, Lobmann R, Mundkowski RG, Luebbert C, Kujath P, Ruf BR, Koch H, Schareck W, Klar E, Drewelow B; Moxifloxacin-DFI Study Group.
Eur J Clin Pharmacol. 2011 Feb;67(2):135-42. doi: 10.1007/s00228-010-0903-5. Epub 2010 Sep 25.

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.
Ramer R, Bublitz K, Freimuth N, Merkord J, Rohde H, Haustein M, Borchert P, Schmuhl E, Linnebacher M, Hinz B.
FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.

Endogenous retrovirus sequences as a novel class of tumor-specific antigens: an example of HERV-H env encoding strong CTL epitopes.
Mullins CS, Linnebacher M.
Cancer Immunol Immunother. 2012 Jul;61(7):1093-100. doi: 10.1007/s00262-011-1183-3. Epub 2011 Dec 21.

Therapeutical doses of temozolomide do not impair the function of dendritic cells and CD8+ T cells.
Xu X, Stockhammer F, Schmitt A, Casalegno-Garduno R, Enders A, Mani J, Classen CF, Linnebacher M, Freund M, Schmitt M.
Int J Oncol. 2012 Mar;40(3):764-72. doi: 10.3892/ijo.2011.1269. Epub 2011 Nov 23.

An MSI tumor specific frameshift mutation in a coding microsatellite of MSH3 encodes for HLA-A0201-restricted CD8+ cytotoxic T cell epitopes.
Garbe Y, Maletzki C, Linnebacher M.
PLoS One. 2011;6(11):e26517. doi: 10.1371/journal.pone.0026517. Epub 2011 Nov 14

Semiallogenic fusions of MSI(+) tumor cells and activated B cells induce MSI-specific T cell responses.
Garbe Y, Klier U, Linnebacher M.
BMC Cancer. 2011 Sep 26;11:410. doi: 10.1186/1471-2407-11-410.

Avitalized bacteria mediate tumor growth control via activation of innate immunity.
Klier U, Maletzki C, Göttmann N, Kreikemeyer B, Linnebacher M.
Cell Immunol. 2011;269(2):120-7. doi: 10.1016/j.cellimm.2011.03.014. Epub 2011 Mar 17.